InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SCIN

Summary

InnateDB Protein

IDBP-8726.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCIN

Protein Name

scinderin

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000297029

InnateDB Gene

IDBG-8722 (SCIN)

Protein Structure

UniProt Annotation

Function

Ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001786	phosphatidylserine binding
GO:0003779	actin binding
GO:0005509	calcium ion binding
GO:0005545	1-phosphatidylinositol binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0051015	actin filament binding

Biological Process

GO:0008285	negative regulation of cell proliferation
GO:0017156	calcium ion-dependent exocytosis
GO:0032330	regulation of chondrocyte differentiation
GO:0043065	positive regulation of apoptotic process
GO:0045010	actin nucleation
GO:0045654	positive regulation of megakaryocyte differentiation
GO:0051014	actin filament severing
GO:0051047	positive regulation of secretion
GO:0051693	actin filament capping