Version 5.4
Homo sapiens Gene: SCIN
Summary
InnateDB Gene IDBG-8722.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCIN
Gene Name scinderin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000006747
Encoded Proteins
IDBP-8724
scinderin
IDBP-8726
scinderin
IDBP-365360
scinderin
IDBP-365363
scinderin
IDBP-477519
scinderin
IDBP-475199
scinderin
IDBP-476994
scinderin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]).[supplied by OMIM, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:12570577-12653603
Strand Forward strand
Band p21.3
Transcripts
ENST00000341757 ENSP00000341375
ENST00000297029 ENSP00000297029
ENST00000417018 ENSP00000404380
ENST00000436854 ENSP00000411149
ENST00000523729 ENSP00000429598
ENST00000518849 ENSP00000428555
ENST00000519209 ENSP00000430997
ENST00000486980
ENST00000473722
ENST00000476649
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001786 phosphatidylserine binding
GO:0003779 actin binding
GO:0005509 calcium ion binding
GO:0005545 1-phosphatidylinositol binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0051015 actin filament binding
Biological Process
GO:0008285 negative regulation of cell proliferation
GO:0017156 calcium ion-dependent exocytosis
GO:0032330 regulation of chondrocyte differentiation
GO:0043065 positive regulation of apoptotic process
GO:0045010 actin nucleation
GO:0045654 positive regulation of megakaryocyte differentiation
GO:0051014 actin filament severing
GO:0051047 positive regulation of secretion
GO:0051693 actin filament capping
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005938 cell cortex
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002565
View Gene Order
ENSBTAG00000009786
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001112706 NM_033128
HUGO
OMIM
CCDS CCDS47545 CCDS47546
HPRD 11539
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca