Version 5.4
Homo sapiens Protein: CNPY3
Summary
InnateDB Protein IDBP-87411.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNPY3
Protein Name canopy 3 homolog (zebrafish)
Synonyms CAG4A; ERDA5; PRAT4A; TNRC5;
Species Homo sapiens
Ensembl Protein ENSP00000361926
InnateDB Gene IDBG-87405 (CNPY3)
Protein Structure
UniProt Annotation
Function Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005788 endoplasmic reticulum lumen
Protein Structure and Domains
PDB ID
InterPro IPR021852 Domain of unknown function DUF3456
PFAM PF11938
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BT09
PhosphoSite PhosphoSite-Q9BT09
TrEMBL
UniProt Splice Variant
Entrez Gene 10695
UniGene
RefSeq NP_006577
HUGO HGNC:11968
OMIM 610774
CCDS CCDS4875
HPRD 06745
IMGT
EMBL AF161347 AK090425 AL035587 AY358960 BC004423 BC008133 BC008898 BC008961 BC022093 U80744
GenPept AAB91442 AAF28907 AAH04423 AAH08898 AAH08961 AAH22093 AAQ89319 BAC03406 CAB75301

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca