Homo sapiens Gene: CNPY3
Summary
InnateDB Gene IDBG-87405.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNPY3
Gene Name canopy 3 homolog (zebrafish)
Synonyms CAG4A; ERDA5; PRAT4A; TNRC5
Species Homo sapiens
Ensembl Gene ENSG00000137161
Encoded Proteins
canopy 3 homolog (zebrafish)
canopy 3 homolog (zebrafish)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
CNPY3 differentially interacts with TLR2, TLR4, and TLR9 and a single-nucleotide change in the CNPY3 gene can influence the strength of TLR responses and may also alter the relative activity of each TLR.
CNPY3 (PRAT4A) is required for TLR-dependent immune responses where it regulates the subcellular distribution and response of multiple TLRs, required for both innate and adaptive immune responses.
Entrez Gene
Summary PRAT4A is associated with the immature form of TLR4 (MIM 603030) and regulates its cell surface expression (Wakabayashi et al., 2006 [PubMed 16849487]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:42929192-42939287
Strand Forward strand
Band p21.1
Transcripts
ENST00000372836 ENSP00000361926
ENST00000394142 ENSP00000377698
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005788 endoplasmic reticulum lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Trafficking and processing of endosomal TLR pathway
Innate Immune System pathway
Toll-Like Receptors Cascades pathway
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9BT09
TrEMBL
UniProt Splice Variant
Entrez Gene 10695
UniGene
RefSeq NM_006586
HUGO HGNC:11968
OMIM 610774
CCDS CCDS4875
HPRD 06745
IMGT
EMBL AF161347 AK090425 AL035587 AY358960 BC004423 BC008133 BC008898 BC008961 BC022093 U80744
GenPept AAB91442 AAF28907 AAH04423 AAH08898 AAH08961 AAH22093 AAQ89319 BAC03406 CAB75301
RNA Seq Atlas 10695