InnateDB Protein
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IDBP-8744.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MTUS1
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Protein Name
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microtubule associated tumor suppressor 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000262102
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InnateDB Gene
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IDBG-8742 (MTUS1)
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Protein Structure
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Function |
Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269PubMed:12692079, ECO:0000269PubMed:19794912}.
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Subcellular Localization |
Mitochondrion {ECO:0000269PubMed:10697957, ECO:0000269PubMed:12692079, ECO:0000269PubMed:19794912}. Golgi apparatus {ECO:0000250}. Cell membrane {ECO:0000250}. Nucleus {ECO:0000250}. Note=In neurons, translocates into the nucleus after treatment with angiotensin-II. {ECO:0000250}.Isoform 1: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes with the mitotic spindle during mitosis and with the intercellular bridge during cytokinesis.
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Disease Associations |
Hepatocellular carcinoma (HCC) [MIM:114550]: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. {ECO:0000269PubMed:16650523}. Note=The gene represented in this entry may be involved in disease pathogenesis.
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Tissue Specificity |
Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain- specific, it is the major isoform in cerebellum and fetal brain. {ECO:0000269PubMed:10697957, ECO:0000269PubMed:12692079, ECO:0000269PubMed:15123706, ECO:0000269PubMed:16270321, ECO:0000269PubMed:16887298, ECO:0000269PubMed:16969489, ECO:0000269PubMed:17656251}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0010758
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regulation of macrophage chemotaxis
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GO:0071375
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cellular response to peptide hormone stimulus
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Cellular Component |
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PDB ID |
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InterPro |
IPR009078
Ferritin-like superfamily
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9ULD2
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PhosphoSite |
PhosphoSite-Q9ULD2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
57509
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UniGene |
Hs.7946
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RefSeq |
NP_001001924
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HUGO |
HGNC:29789
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OMIM |
609589
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CCDS |
CCDS43717
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HPRD |
11376
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IMGT |
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EMBL |
AB033114
AC027117
AC124069
AF121259
AF293357
AK024357
AK125188
AK289750
AK294860
AK314692
AL096842
AY363099
BC007328
BC033842
BC136320
BC142971
BX648879
CH471080
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GenPept |
AAG33674
AAH07328
AAH33842
AAI36321
AAI42972
AAL37035
AAQ24172
BAA86602
BAB14894
BAF82439
BAG37243
BAG54161
BAG57964
CAB50791
CAH56128
EAW63804
EAW63805
EAW63810
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