InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DNAJC5

Summary

InnateDB Protein

IDBP-87442.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNAJC5

Protein Name

DnaJ (Hsp40) homolog, subfamily C, member 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000354111

InnateDB Gene

IDBG-87436 (DNAJC5)

Protein Structure

UniProt Annotation

Function

May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Melanosome. Cell membrane. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Disease Associations

Ceroid lipofuscinosis, neuronal, 4B (CLN4B) [MIM:162350]: An adult-onset neuronal ceroid lipofuscinosis. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. CLN4B has no visual involvement and is characterized by seizures and other neurologic symptoms. {ECO:0000269PubMed:21820099, ECO:0000269PubMed:22073189, ECO:0000269PubMed:22235333, ECO:0000269PubMed:22978711}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart. {ECO:0000269PubMed:8764987}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0043008	ATP-dependent protein binding

Biological Process

GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0008219	cell death
GO:0043524	negative regulation of neuron apoptotic process

Cellular Component

GO:0005739	mitochondrion
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0042470	melanosome
GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
GO:0070062	extracellular vesicular exosome