InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MTUS1

Summary

InnateDB Protein

IDBP-8750.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTUS1

Protein Name

microtubule associated tumor suppressor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000371285

InnateDB Gene

IDBG-8742 (MTUS1)

Protein Structure

UniProt Annotation

Function

Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269PubMed:12692079, ECO:0000269PubMed:19794912}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:10697957, ECO:0000269PubMed:12692079, ECO:0000269PubMed:19794912}. Golgi apparatus {ECO:0000250}. Cell membrane {ECO:0000250}. Nucleus {ECO:0000250}. Note=In neurons, translocates into the nucleus after treatment with angiotensin-II. {ECO:0000250}.Isoform 1: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes with the mitotic spindle during mitosis and with the intercellular bridge during cytokinesis.

Disease Associations

Hepatocellular carcinoma (HCC) [MIM:114550]: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. {ECO:0000269PubMed:16650523}. Note=The gene represented in this entry may be involved in disease pathogenesis.

Tissue Specificity

Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain- specific, it is the major isoform in cerebellum and fetal brain. {ECO:0000269PubMed:10697957, ECO:0000269PubMed:12692079, ECO:0000269PubMed:15123706, ECO:0000269PubMed:16270321, ECO:0000269PubMed:16887298, ECO:0000269PubMed:16969489, ECO:0000269PubMed:17656251}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005794	Golgi apparatus
GO:0005815	microtubule organizing center
GO:0005819	spindle
GO:0005874	microtubule
GO:0005886	plasma membrane