InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ICMT

Summary

InnateDB Protein

IDBP-87500.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ICMT

Protein Name

isoprenylcysteine carboxyl methyltransferase

Synonyms

HSTE14; MST098; MSTP098; PCCMT; PCMT; PPMT;

Species

Homo sapiens

Ensembl Protein

ENSP00000343552

InnateDB Gene

IDBG-87498 (ICMT)

Protein Structure

UniProt Annotation

Function

Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:19158273}; Multi-pass membrane protein {ECO:0000269PubMed:19158273}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons. {ECO:0000269PubMed:10649571}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003880	protein C-terminal carboxyl O-methyltransferase activity
GO:0004671	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
GO:0008140	cAMP response element binding protein binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001889	liver development
GO:0006464	cellular protein modification process
GO:0006479	protein methylation
GO:0006481	C-terminal protein methylation
GO:0006612	protein targeting to membrane
GO:0008104	protein localization
GO:0008284	positive regulation of cell proliferation
GO:0035264	multicellular organism growth
GO:0046578	regulation of Ras protein signal transduction
GO:2001141	regulation of RNA biosynthetic process