Version 5.4
Homo sapiens Gene: ICMT
Summary
InnateDB Gene IDBG-87498.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ICMT
Gene Name isoprenylcysteine carboxyl methyltransferase
Synonyms HSTE14; MST098; MSTP098; PCCMT; PCMT; PPMT
Species Homo sapiens
Ensembl Gene ENSG00000116237
Encoded Proteins
IDBP-87500
isoprenylcysteine carboxyl methyltransferase
IDBP-721849
IDBP-721775
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:6221193-6235972
Strand Reverse strand
Band p36.31
Transcripts
ENST00000343813 ENSP00000343552
ENST00000495791
ENST00000489498 ENSP00000466222
ENST00000474756 ENSP00000467999
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003880 protein C-terminal carboxyl O-methyltransferase activity
GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
GO:0008140 cAMP response element binding protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001889 liver development
GO:0006464 cellular protein modification process
GO:0006479 protein methylation
GO:0006481 C-terminal protein methylation
GO:0006612 protein targeting to membrane
GO:0008104 protein localization
GO:0008284 positive regulation of cell proliferation
GO:0035264 multicellular organism growth
GO:0046578 regulation of Ras protein signal transduction
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039662
View Gene Order
ENSBTAG00000048308
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00900
Terpenoid backbone biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL K7EQW0 Q7Z750
UniProt Splice Variant
Entrez Gene 23463
UniGene Hs.515688 Hs.606542 Hs.708640
RefSeq NM_012405 XM_005263437
HUGO HGNC:5350
OMIM 605851
CCDS CCDS61
HPRD 09321
IMGT
EMBL AL031847
GenPept
RNA Seq Atlas 23463

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca