InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNIP2

Summary

InnateDB Protein

IDBP-87534.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNIP2

Protein Name

Kv channel interacting protein 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000239118

InnateDB Gene

IDBG-87532 (KCNIP2)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface (By similarity). {ECO:0000250}.

Subcellular Localization

Isoform 1: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.Isoform 2: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.Isoform 6: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells. Isoform 3 is expressed in heart and in umbilical vein endothelial cells. Not expressed in fetal heart. {ECO:0000269PubMed:11263977, ECO:0000269PubMed:11684073, ECO:0000269PubMed:15356203}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005250	A-type (transient outward) potassium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0015459	potassium channel regulator activity
GO:0042802	identical protein binding
GO:0044325	ion channel binding
GO:0046923	ER retention sequence binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0005513	detection of calcium ion
GO:0006813	potassium ion transport
GO:0006936	muscle contraction
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0008016	regulation of heart contraction
GO:0045163	clustering of voltage-gated potassium channels
GO:0071435	potassium ion export
GO:0071805	potassium ion transmembrane transport
GO:0086009	membrane repolarization
GO:2001257	regulation of cation channel activity