Version 5.4
Homo sapiens Gene: KCNIP2
Summary
InnateDB Gene IDBG-87532.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNIP2
Gene Name Kv channel interacting protein 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000120049
Encoded Proteins
IDBP-87534
Kv channel interacting protein 2
IDBP-87536
Kv channel interacting protein 2
IDBP-87540
Kv channel interacting protein 2
IDBP-87542
Kv channel interacting protein 2
IDBP-87544
Kv channel interacting protein 2
IDBP-87554
Kv channel interacting protein 2
IDBP-87556
Kv channel interacting protein 2
IDBP-384798
Kv channel interacting protein 2
IDBP-483010
Kv channel interacting protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:101825974-101843920
Strand Reverse strand
Band q24.32
Transcripts
ENST00000348850 ENSP00000239118
ENST00000358038 ENSP00000350733
ENST00000355657
ENST00000356640 ENSP00000349055
ENST00000353068 ENSP00000341624
ENST00000343195 ENSP00000344169
ENST00000370046 ENSP00000359063
ENST00000239117 ENSP00000239117
ENST00000434163 ENSP00000411679
ENST00000460388
ENST00000472764
ENST00000461105 ENSP00000420040
ENST00000483385
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005250 A-type (transient outward) potassium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0015459 potassium channel regulator activity
GO:0042802 identical protein binding
GO:0044325 ion channel binding
GO:0046923 ER retention sequence binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0005513 detection of calcium ion
GO:0006813 potassium ion transport
GO:0006936 muscle contraction
GO:0007165 signal transduction
GO:0007268 synaptic transmission
GO:0008016 regulation of heart contraction
GO:0045163 clustering of voltage-gated potassium channels
GO:0071435 potassium ion export
GO:0071805 potassium ion transmembrane transport
GO:0086009 membrane repolarization
GO:2001257 regulation of cation channel activity
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005737 cytoplasm
GO:0008076 voltage-gated potassium channel complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025221
View Gene Order
ENSBTAG00000016343
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.97044
RefSeq NM_014591 NM_173191 NM_173192 NM_173193 NM_173194 NM_173195 NM_173197
HUGO
OMIM
CCDS CCDS41562 CCDS7521 CCDS7522 CCDS7523 CCDS7524 CCDS7525 CCDS7526
HPRD 06880
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca