InnateDB Protein
|
IDBP-87536.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
KCNIP2
|
Protein Name
|
Kv channel interacting protein 2
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000350733
|
InnateDB Gene
|
IDBG-87532 (KCNIP2)
|
Protein Structure
|
|
Function |
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Isoform 1: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.Isoform 2: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.Isoform 6: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Expressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells. Isoform 3 is expressed in heart and in umbilical vein endothelial cells. Not expressed in fetal heart. {ECO:0000269PubMed:11263977, ECO:0000269PubMed:11684073, ECO:0000269PubMed:15356203}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
|
Protein-Protein |
9
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR002048
EF-hand domain
|
PFAM |
PF00036
PF13202
PF13405
|
PRINTS |
|
PIRSF |
|
SMART |
SM00054
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9NS61
|
PhosphoSite |
PhosphoSite-Q9NS61
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
30819
|
UniGene |
Hs.97044
|
RefSeq |
NP_775284
|
HUGO |
HGNC:15522
|
OMIM |
604661
|
CCDS |
CCDS41562
|
HPRD |
06880
|
IMGT |
|
EMBL |
AB044584
AB044585
AC010789
AF199598
AF295076
AF295530
AF347114
AF367018
AF367019
AF367020
AF367021
AJ276317
AK027347
AK315042
AL136722
AY026328
AY026329
AY026330
AY026331
AY302141
BC034685
CH471066
DQ148480
DQ148481
DQ148483
|
GenPept |
AAF33683
AAG02120
AAG02121
AAH34685
AAK07674
AAK21972
AAK53707
AAK53708
AAK53709
AAK53710
AAK70356
AAP57633
AAZ77797
AAZ77798
AAZ77800
BAA96740
BAA96741
BAB55052
BAG37523
CAB66656
CAB77054
EAW49733
|
|
|