InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HES3

Summary

InnateDB Protein

IDBP-87569.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HES3

Protein Name

hairy and enhancer of split 3 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000367130

InnateDB Gene

IDBG-87565 (HES3)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor of genes that require a bHLH protein for their transcription. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0008134	transcription factor binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0006351	transcription, DNA-templated
GO:0021555	midbrain-hindbrain boundary morphogenesis
GO:0021557	oculomotor nerve development
GO:0021558	trochlear nerve development
GO:0021575	hindbrain morphogenesis
GO:0021915	neural tube development
GO:0030901	midbrain development
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050767	regulation of neurogenesis
GO:0060164	regulation of timing of neuron differentiation