InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACOT7

Summary

InnateDB Protein

IDBP-87605.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACOT7

Protein Name

acyl-CoA thioesterase 7

Synonyms

ACH1; ACT; BACH; CTE-II; hBACH; LACH; LACH1;

Species

Homo sapiens

Ensembl Protein

ENSP00000367086

InnateDB Gene

IDBG-87595 (ACOT7)

Protein Structure

UniProt Annotation

Function

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl- CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA.

Subcellular Localization

Isoform 4: Cytoplasm.Isoform 6: Cytoplasm.Isoform 1: Mitochondrion.Isoform 5: Mitochondrion.

Disease Associations

Tissue Specificity

Isoform 4 is expressed exclusively in brain. {ECO:0000269PubMed:12435388}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000062	fatty-acyl-CoA binding
GO:0005515	protein binding
GO:0016290	palmitoyl-CoA hydrolase activity
GO:0036042	long-chain fatty acyl-CoA binding
GO:0042803	protein homodimerization activity
GO:0047617	acyl-CoA hydrolase activity

Biological Process

GO:0009062	fatty acid catabolic process
GO:0015937	coenzyme A biosynthetic process
GO:0036114	medium-chain fatty-acyl-CoA catabolic process
GO:0036116	long-chain fatty-acyl-CoA catabolic process
GO:0051792	medium-chain fatty acid biosynthetic process
GO:1900535	palmitic acid biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0043005	neuron projection
GO:0044297	cell body
GO:0070062	extracellular vesicular exosome