Version 5.4
Homo sapiens Gene: ACOT7
Summary
InnateDB Gene IDBG-87595.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACOT7
Gene Name acyl-CoA thioesterase 7
Synonyms ACH1; ACT; BACH; CTE-II; hBACH; LACH; LACH1
Species Homo sapiens
Ensembl Gene ENSG00000097021
Encoded Proteins
IDBP-87599
acyl-CoA thioesterase 7
IDBP-87603
acyl-CoA thioesterase 7
IDBP-87605
acyl-CoA thioesterase 7
IDBP-87607
acyl-CoA thioesterase 7
IDBP-87609
acyl-CoA thioesterase 7
IDBP-365362
acyl-CoA thioesterase 7
IDBP-721945
IDBP-591620
acyl-CoA thioesterase 7
IDBP-808504
acyl-CoA thioesterase 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:6264269-6394391
Strand Reverse strand
Band p36.31
Transcripts
ENST00000377860 ENSP00000367091
ENST00000361521 ENSP00000354615
ENST00000377855 ENSP00000367086
ENST00000377845 ENSP00000367076
ENST00000377842 ENSP00000367073
ENST00000418124 ENSP00000402532
ENST00000473466 ENSP00000465719
ENST00000481175
ENST00000545482 ENSP00000439218
ENST00000608083 ENSP00000476610
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000062 fatty-acyl-CoA binding
GO:0005515 protein binding
GO:0016290 palmitoyl-CoA hydrolase activity
GO:0036042 long-chain fatty acyl-CoA binding
GO:0042803 protein homodimerization activity
GO:0047617 acyl-CoA hydrolase activity
Biological Process
GO:0009062 fatty acid catabolic process
GO:0015937 coenzyme A biosynthetic process
GO:0036114 medium-chain fatty-acyl-CoA catabolic process
GO:0036116 long-chain fatty-acyl-CoA catabolic process
GO:0051792 medium-chain fatty acid biosynthetic process
GO:1900535 palmitic acid biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0043005 neuron projection
GO:0044297 cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028937
View Gene Order
ENSBTAG00000021202
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa01040
Biosynthesis of unsaturated fatty acids pathway
hsa00062
Fatty acid elongation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.126137 Hs.599325
RefSeq NM_007274 NM_181864 NM_181865 NM_181866
HUGO
OMIM
CCDS CCDS30573 CCDS65 CCDS66 CCDS67
HPRD 12517
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca