Version 5.4
Homo sapiens Protein: HES2
Summary
InnateDB Protein IDBP-87667.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HES2
Protein Name hairy and enhancer of split 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000367065
InnateDB Gene IDBG-87661 (HES2)
Protein Structure
UniProt Annotation
Function Transcriptional repressor of genes that require a bHLH protein for their transcription. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00380, ECO:0000255PROSITE-ProRule:PRU00981}.
Disease Associations
Tissue Specificity Expressed in placenta, pancreatic cancer, colon cancer with RER, cervical cancer, and in head and neck tumors. {ECO:0000269PubMed:15254753}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0008134 transcription factor binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR003650 Orange
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR018352 Orange subgroup
PFAM PF07527
PF00010
PRINTS
PIRSF
SMART SM00353
SM00511
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y543
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 54626
UniGene Hs.734685
RefSeq NP_061962
HUGO HGNC:16005
OMIM 609970
CCDS CCDS30574
HPRD 13649
IMGT
EMBL AK091122 AL031848 BC012091 BC132698 BC136963 BC142687 CH471130
GenPept AAH12091 AAI32699 AAI36964 AAI42688 BAG52286 CAB46198 CAB46199 EAW71533

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca