InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNFRSF25

Summary

InnateDB Protein

IDBP-87701.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFRSF25

Protein Name

tumor necrosis factor receptor superfamily, member 25

Synonyms

APO-3; DDR3; DR3; LARD; TNFRSF12; TR3; TRAMP; WSL-1; WSL-LR;

Species

Homo sapiens

Ensembl Protein

ENSP00000314451

InnateDB Gene

IDBG-227097 (TNFRSF25)

Protein Structure

UniProt Annotation

Function

Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.

Subcellular Localization

Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Cell membrane; Single-pass type I membrane protein.Isoform 9: Cell membrane; Single-pass type I membrane protein.Isoform 11: Cell membrane; Single-pass type I membrane protein.Isoform 3: Secreted.Isoform 4: Secreted.Isoform 5: Secreted.Isoform 6: Secreted.Isoform 7: Secreted.Isoform 8: Secreted.Isoform 10: Secreted.Isoform 12: Secreted.

Disease Associations

Tissue Specificity

Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005031	tumor necrosis factor-activated receptor activity
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0042981	regulation of apoptotic process
GO:0097190	apoptotic signaling pathway