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InnateDB Protein
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IDBP-87795.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PPRC1
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Protein Name
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peroxisome proliferator-activated receptor gamma, coactivator-related 1
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Synonyms
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PRC;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000359029
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InnateDB Gene
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IDBG-87791 (PPRC1)
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Protein Structure
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| Function |
Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. {ECO:0000269PubMed:11340167, ECO:0000269PubMed:16908542}.
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| Subcellular Localization |
Nucleus {ECO:0000269PubMed:11340167}. Note=Colocalizes with NRF1. {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors. {ECO:0000269PubMed:11340167, ECO:0000269PubMed:14550271}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
5
[view]
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| Protein-Protein |
5
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
1 [view]
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Molecular Function |
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| Biological Process |
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR000504
RNA recognition motif domain
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| PFAM |
PF00076
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| PRINTS |
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| PIRSF |
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| SMART |
SM00360
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q5VV67
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| TrEMBL |
X6R7H2
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| UniProt Splice Variant |
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| Entrez Gene |
23082
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| UniGene |
Hs.533551
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| RefSeq |
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| HUGO |
HGNC:30025
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| OMIM |
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| CCDS |
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| HPRD |
15173
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| IMGT |
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| EMBL |
AL500527
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| GenPept |
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Version 5.4