InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MCF2

Summary

InnateDB Protein

IDBP-87867.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MCF2

Protein Name

MCF.2 cell line derived transforming sequence

Synonyms

ARHGEF21; DBL;

Species

Homo sapiens

Ensembl Protein

ENSP00000359605

InnateDB Gene

IDBG-87861 (MCF2)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15157669}.Isoform 1: Membrane.Isoform 3: Membrane. Note=Colocalizes with CDC42 to plasma membrane.

Disease Associations

Note=MCF2 and DBL represent two activated versions of the same proto-oncogene.

Tissue Specificity

Isoform 1 is expressed only in brain. Isoform 3 is expressed in heart, kidney, spleen, liver and testis. Isoform 4 is expressed in brain, heart, kidney, testis, placenta, stomach and peripheral blood. The protein is detectable in brain, heart, kidney, intestine, muscle, lung and testis. {ECO:0000269PubMed:12445822}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway