Version 5.4
Homo sapiens Protein: SLC22A7
Summary
InnateDB Protein IDBP-87937.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC22A7
Protein Name solute carrier family 22 (organic anion transporter), member 7
Synonyms NLT; OAT2;
Species Homo sapiens
Ensembl Protein ENSP00000361670
InnateDB Gene IDBG-87931 (SLC22A7)
Protein Structure
UniProt Annotation
Function Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate. {ECO:0000269PubMed:11327718, ECO:0000269PubMed:11855680, ECO:0000269PubMed:11907186, ECO:0000269PubMed:12023506, ECO:0000269PubMed:15901346}.
Subcellular Localization Basolateral cell membrane {ECO:0000269PubMed:11907186, ECO:0000269PubMed:12023506}; Multi- pass membrane protein {ECO:0000269PubMed:11907186, ECO:0000269PubMed:12023506}. Note=Apical side of the renal tubule.
Disease Associations
Tissue Specificity Expressed in liver and kidney. {ECO:0000269PubMed:11327718, ECO:0000269PubMed:11907186, ECO:0000269PubMed:15901346}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0015075 ion transmembrane transporter activity
GO:0015347 sodium-independent organic anion transmembrane transporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0015711 organic anion transport
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR004749 Organic cation transport protein
IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain
PFAM PF00083
PF07690
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y694
PhosphoSite PhosphoSite-Q9Y694
TrEMBL
UniProt Splice Variant
Entrez Gene 10864
UniGene Hs.485438
RefSeq NP_006663
HUGO HGNC:10971
OMIM 604995
CCDS CCDS4892
HPRD 05409
IMGT
EMBL AF097518 AF210455 AK290796 AK290806 AL583834 AY050498 BC033805 CH471081 EU562669
GenPept AAD37091 AAG43523 AAH33805 AAL12496 ACB21045 BAF83485 BAF83495 CAI14462 CAI14463 CAI14464 CAI14466 EAX04172 EAX04175

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca