InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FBXL15

Summary

InnateDB Protein

IDBP-87966.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXL15

Protein Name

F-box and leucine-rich repeat protein 15

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000358972

InnateDB Gene

IDBG-87962 (FBXL15)

Protein Structure

UniProt Annotation

Function

Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2. {ECO:0000269PubMed:21572392}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:21572392}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0009953	dorsal/ventral pattern formation
GO:0016567	protein ubiquitination
GO:0030282	bone mineralization
GO:0030513	positive regulation of BMP signaling pathway
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process