Version 5.4
Homo sapiens Protein: ZBTB48
Summary
InnateDB Protein IDBP-88001.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZBTB48
Protein Name zinc finger and BTB domain containing 48
Synonyms HKR3; pp9964; ZNF855;
Species Homo sapiens
Ensembl Protein ENSP00000366902
InnateDB Gene IDBG-87999 (ZBTB48)
Protein Structure
UniProt Annotation
Function Binds to and regulates the J and/or S elements in MHC II promoter. {ECO:0000269PubMed:7969177}.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity Detected in adrenal gland and neuroblastoma. {ECO:0000269PubMed:9516840}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 26 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000210 BTB/POZ-like
IPR007087 Zinc finger, C2H2
IPR011333 BTB/POZ fold
IPR013069 BTB/POZ
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PF00651
PRINTS
PIRSF
SMART SM00225
SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P10074
PhosphoSite PhosphoSite-P10074
TrEMBL Q6LCP1
UniProt Splice Variant
Entrez Gene 3104
UniGene Hs.502330
RefSeq NP_005332
HUGO HGNC:4930
OMIM 165270
CCDS CCDS84
HPRD 01316
IMGT
EMBL AL591866 BC013573 L16896 M20677 U45324 U45325
GenPept AAA35989 AAA65124 AAB08973 AAB08974 AAH13573 CAI16079

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca