Version 5.4
Homo sapiens Protein: ABCC10
Summary
InnateDB Protein IDBP-88089.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABCC10
Protein Name ATP-binding cassette, sub-family C (CFTR/MRP), member 10
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000244533
InnateDB Gene IDBG-88083 (ABCC10)
Protein Structure
UniProt Annotation
Function ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion. {ECO:0000269PubMed:12527806, ECO:0000269PubMed:15256465}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:12566991, ECO:0000269PubMed:15256465}; Multi-pass membrane protein {ECO:0000255PROSITE-ProRule:PRU00441, ECO:0000269PubMed:12566991, ECO:0000269PubMed:15256465}.
Disease Associations
Tissue Specificity Isoform 1 is specifically expressed in spleen. Isoform 2 is more widely expressed. {ECO:0000269PubMed:12566991}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
Biological Process
GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001140 ABC transporter, transmembrane domain
IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR011527 ABC transporter type 1, transmembrane domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00664
PF13748
PF00005
PRINTS
PIRSF
SMART SM00382
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5T3U5
PhosphoSite PhosphoSite-Q5T3U5
TrEMBL Q9UFG1
UniProt Splice Variant
Entrez Gene 89845
UniGene Hs.742827
RefSeq NP_258261
HUGO HGNC:52
OMIM 612509
CCDS CCDS4896
HPRD 07623
IMGT
EMBL AK000002 AK024446 AL122095 AL133613 AL359813 AY032599 BC024103
GenPept AAH24103 AAK39642 BAA92227 BAB15736 CAB59263 CAB63742 CAI23217

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca