InnateDB Protein
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IDBP-88304.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PARK7
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Protein Name
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parkinson protein 7
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Synonyms
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DJ-1; DJ1; HEL-S-67p;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000366711
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InnateDB Gene
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IDBG-88298 (PARK7)
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Protein Structure
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Function |
Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone. May regulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells. {ECO:0000269PubMed:11477070, ECO:0000269PubMed:12612053, ECO:0000269PubMed:12939276, ECO:0000269PubMed:14749723, ECO:0000269PubMed:15181200, ECO:0000269PubMed:15502874, ECO:0000269PubMed:15976810, ECO:0000269PubMed:16390825, ECO:0000269PubMed:17015834, ECO:0000269PubMed:18626009, ECO:0000269PubMed:18711745, ECO:0000269PubMed:20304780, ECO:0000269PubMed:21097510, ECO:0000269PubMed:23847046, ECO:0000269PubMed:9070310}.
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Subcellular Localization |
Cell membrane; Lipid-anchor. Cytoplasm. Nucleus. Membrane raft. Mitochondrion. Note=Under normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion. Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against oxidative damage. Detected in tau inclusions in brains from neurodegenerative disease patients. Membrane raft localization in astrocytes and neuronal cells requires palmitoylation.
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Disease Associations |
Parkinson disease 7 (PARK7) [MIM:606324]: A neurodegenerative disorder characterized by resting tremor, postural tremor, bradykinesia, muscular rigidity, anxiety and psychotic episodes. PARK7 has onset before 40 years, slow progression and initial good response to levodopa. Some patients may show traits reminiscent of amyotrophic lateral sclerosis- parkinsonism/dementia complex (Guam disease). {ECO:0000269PubMed:12446870, ECO:0000269PubMed:12953260, ECO:0000269PubMed:15254937, ECO:0000269PubMed:15365989}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart. Detected at slightly lower levels in placenta and brain. Detected in astrocytes, Sertoli cells, spermatogonia, spermatids and spermatozoa. {ECO:0000269PubMed:14579415, ECO:0000269PubMed:14662519, ECO:0000269PubMed:14705119, ECO:0000269PubMed:9070310}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 90 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated |
Total |
90
[view]
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Protein-Protein |
89
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
10 [view]
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Molecular Function |
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Biological Process |
GO:0001933
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negative regulation of protein phosphorylation
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GO:0006469
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negative regulation of protein kinase activity
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GO:0006508
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proteolysis
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GO:0006914
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autophagy
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GO:0006954
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inflammatory response
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GO:0007005
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mitochondrion organization
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GO:0007338
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single fertilization
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GO:0010629
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negative regulation of gene expression
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GO:0032091
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negative regulation of protein binding
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GO:0032757
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positive regulation of interleukin-8 production
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GO:0034599
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cellular response to oxidative stress
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GO:0042743
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hydrogen peroxide metabolic process
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GO:0043523
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regulation of neuron apoptotic process
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GO:0043524
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negative regulation of neuron apoptotic process
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0046826
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negative regulation of protein export from nucleus
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GO:0050727
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regulation of inflammatory response
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GO:0050821
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protein stabilization
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GO:0051881
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regulation of mitochondrial membrane potential
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GO:0055114
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oxidation-reduction process
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GO:0060548
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negative regulation of cell death
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GO:0060765
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regulation of androgen receptor signaling pathway
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GO:0070301
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cellular response to hydrogen peroxide
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GO:0090073
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positive regulation of protein homodimerization activity
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GO:1900182
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positive regulation of protein localization to nucleus
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GO:1901215
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negative regulation of neuron death
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GO:1901299
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negative regulation of hydrogen peroxide-mediated programmed cell death
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GO:1901671
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positive regulation of superoxide dismutase activity
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GO:1901984
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negative regulation of protein acetylation
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GO:1903073
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negative regulation of death-inducing signaling complex assembly
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GO:1903094
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negative regulation of protein K48-linked deubiquitination
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GO:1903122
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negative regulation of TRAIL-activated apoptotic signaling pathway
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GO:2000157
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negative regulation of ubiquitin-specific protease activity
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GO:2000825
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positive regulation of androgen receptor activity
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GO:2001237
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negative regulation of extrinsic apoptotic signaling pathway
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GO:2001268
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negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR002818
ThiJ/PfpI
IPR006287
DJ-1
IPR029062
Class I glutamine amidotransferase-like
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PFAM |
PF01965
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q99497
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PhosphoSite |
PhosphoSite-Q99497
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TrEMBL |
V9HWC2
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UniProt Splice Variant |
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Entrez Gene |
11315
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UniGene |
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RefSeq |
XP_005263481
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HUGO |
HGNC:16369
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OMIM |
602533
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CCDS |
CCDS93
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HPRD |
03961
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IMGT |
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EMBL |
AB045294
AB073864
AF021819
AK312000
AL034417
AY648999
BC008188
CH471130
D61380
EU794641
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GenPept |
AAC12806
AAH08188
AAT68961
ACJ13695
BAA09603
BAB71782
BAG34938
CAB52550
EAW71591
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