InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RERE

Summary

InnateDB Protein

IDBP-88371.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RERE

Protein Name

arginine-glutamic acid dipeptide (RE) repeats

Synonyms

ARG; ARP; ATN1L; DNB1;

Species

Homo sapiens

Ensembl Protein

ENSP00000338629

InnateDB Gene

IDBG-88369 (RERE)

Protein Structure

UniProt Annotation

Function

Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. {ECO:0000269PubMed:11331249}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00512, ECO:0000255PROSITE-ProRule:PRU00624, ECO:0000269PubMed:10814707, ECO:0000269PubMed:11331249}. Note=Localized in nuclear bodies of variables size. Colocalized with PML and BAX in nuclear PODs.

Disease Associations

Note=A chromosomal aberration involving RERE is found in the neuroblastoma cell line NGP. Translocation t(1;15)(p36.2;q24).

Tissue Specificity

Widely expressed. Expressed in tumor cell lines. {ECO:0000269PubMed:10729226, ECO:0000269PubMed:10814707, ECO:0000269PubMed:11331249}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008267	poly-glutamine tract binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006607	NLS-bearing protein import into nucleus
GO:0007275	multicellular organismal development

Cellular Component

GO:0000118	histone deacetylase complex
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000679 Zinc finger, GATA-type
IPR000949 ELM2 domain
IPR001005 SANT/Myb domain
IPR001025 Bromo adjacent homology (BAH) domain
IPR002951 Atrophin-like
IPR009057 Homeodomain-like

PFAM

PF00320
PF01448
PF00249
PF01426
PF03154

PRINTS

PR00619

PIRSF

SMART

SM00401
SM00717
SM00439

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt