InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTNNBIP1

Summary

InnateDB Protein

IDBP-88715.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTNNBIP1

Protein Name

catenin, beta interacting protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000366466

InnateDB Gene

IDBG-88705 (CTNNBIP1)

Protein Structure

UniProt Annotation

Function

Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. {ECO:0000269PubMed:12408824}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0070016	armadillo repeat domain binding

Biological Process

GO:0001658	branching involved in ureteric bud morphogenesis
GO:0002528	regulation of vascular permeability involved in acute inflammatory response
GO:0009952	anterior/posterior pattern specification
GO:0030178	negative regulation of Wnt signaling pathway
GO:0032091	negative regulation of protein binding
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045657	positive regulation of monocyte differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0072201	negative regulation of mesenchymal cell proliferation