InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CTNNBIP1

Summary

InnateDB Gene

IDBG-88705.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTNNBIP1

Gene Name

catenin, beta interacting protein 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000178585

Encoded Proteins

IDBP-88707

catenin, beta interacting protein 1

IDBP-88713

catenin, beta interacting protein 1

IDBP-88715

catenin, beta interacting protein 1

IDBP-227121

catenin, beta interacting protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:9848276-9910336

Strand

Reverse strand

Band

p36.22

Transcripts

ENST00000377263	ENSP00000366474
ENST00000377258	ENSP00000366468
ENST00000377256	ENSP00000366466
ENST00000400904	ENSP00000383696

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0070016	armadillo repeat domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0002528	regulation of vascular permeability involved in acute inflammatory response
GO:0009952	anterior/posterior pattern specification
GO:0016055	Wnt signaling pathway
GO:0030178	negative regulation of Wnt signaling pathway
GO:0031333	negative regulation of protein complex assembly
GO:0032091	negative regulation of protein binding
GO:0043392	negative regulation of DNA binding
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045657	positive regulation of monocyte differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0060633	negative regulation of transcription initiation from RNA polymerase II promoter
GO:0072201	negative regulation of mesenchymal cell proliferation