Version 5.4
Homo sapiens Protein: SORCS3
Summary
InnateDB Protein IDBP-88953.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SORCS3
Protein Name sortilin-related VPS10 domain containing receptor 3
Synonyms SORCS;
Species Homo sapiens
Ensembl Protein ENSP00000358715
InnateDB Gene IDBG-88951 (SORCS3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Highly expressed in brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008188 neuropeptide receptor activity
Biological Process
GO:0007218 neuropeptide signaling pathway
GO:0007612 learning
GO:0007613 memory
GO:1900452 regulation of long term synaptic depression
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0097481 neuronal postsynaptic density
Protein Structure and Domains
PDB ID
InterPro IPR000601 PKD domain
IPR006581 VPS10
PFAM PF00801
PRINTS
PIRSF
SMART SM00602
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UPU3
PhosphoSite PhosphoSite-Q9UPU3
TrEMBL B7Z891
UniProt Splice Variant
Entrez Gene 22986
UniGene Hs.671950
RefSeq NP_055793
HUGO HGNC:16699
OMIM 606285
CCDS CCDS7558
HPRD 12100
IMGT
EMBL AB028982 AK303009 AL161646 AL353900 AL355350 AL358949 AL365449 AL445492 AL589942 AL596118
GenPept BAA83011 BAH13877 CAH70023 CAH70335 CAH70477 CAH70813 CAH72221 CAI64579

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca