Version 5.4
Homo sapiens Gene: SORCS3
Summary
InnateDB Gene IDBG-88951.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SORCS3
Gene Name sortilin-related VPS10 domain containing receptor 3
Synonyms SORCS
Species Homo sapiens
Ensembl Gene ENSG00000156395
Encoded Proteins
IDBP-88953
sortilin-related VPS10 domain containing receptor 3
IDBP-88955
sortilin-related VPS10 domain containing receptor 3
IDBP-244144
sortilin-related VPS10 domain containing receptor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:104641101-105265235
Strand Forward strand
Band q25.1
Transcripts
ENST00000369701 ENSP00000358715
ENST00000369699 ENSP00000358713
ENST00000393176 ENSP00000376876
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008188 neuropeptide receptor activity
Biological Process
GO:0007218 neuropeptide signaling pathway
GO:0007612 learning
GO:0007613 memory
GO:1900452 regulation of long term synaptic depression
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0097481 neuronal postsynaptic density
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000063434
View Gene Order
Cross-References
SwissProt
TrEMBL Q5CAJ2
UniProt Splice Variant
Entrez Gene 22986
UniGene Hs.671950
RefSeq NM_014978
HUGO HGNC:16699
OMIM 606285
CCDS CCDS7558
HPRD 12100
IMGT
EMBL AL161646 AL353900 AL355350 AL358949 AL365449 AL445492 AL589942 AL596118
GenPept
RNA Seq Atlas 22986

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca