InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DOLPP1

Summary

InnateDB Protein

IDBP-88963.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DOLPP1

Protein Name

dolichyl pyrophosphate phosphatase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000361625

InnateDB Gene

IDBG-88961 (DOLPP1)

Protein Structure

UniProt Annotation

Function

Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate (By similarity). {ECO:0000250UniProtKB:Q9JMF7}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0047874	dolichyldiphosphatase activity

Biological Process

GO:0006487	protein N-linked glycosylation
GO:0006488	dolichol-linked oligosaccharide biosynthetic process
GO:0006489	dolichyl diphosphate biosynthetic process
GO:0008610	lipid biosynthetic process
GO:0018279	protein N-linked glycosylation via asparagine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process