InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SOSTDC1

Summary

InnateDB Protein

IDBP-8902.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOSTDC1

Protein Name

sclerostin domain containing 1

Synonyms

ECTODIN; USAG1;

Species

Homo sapiens

Ensembl Protein

ENSP00000304930

InnateDB Gene

IDBG-8900 (SOSTDC1)

Protein Structure

UniProt Annotation

Function

May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner. {ECO:0000250, ECO:0000269PubMed:15020244}.

Subcellular Localization

Secreted {ECO:0000269PubMed:15020244}.

Disease Associations

Tissue Specificity

Highly expressed in kidney and weakly in lung. {ECO:0000269PubMed:15020244}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007389	pattern specification process
GO:0010454	negative regulation of cell fate commitment
GO:0016055	Wnt signaling pathway
GO:0030514	negative regulation of BMP signaling pathway
GO:0031069	hair follicle morphogenesis
GO:0042475	odontogenesis of dentin-containing tooth
GO:0060648	mammary gland bud morphogenesis
GO:0090090	negative regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005615

extracellular space

Protein Structure and Domains

PDB ID

InterPro

IPR004133 DAN
IPR006207 Cystine knot, C-terminal
IPR006208 Glycoprotein hormone subunit beta, cystine knot
IPR008835 Sclerostin/Sclerostin domain-containing protein 1
IPR029034 Cystine-knot cytokine

PFAM

PF03045
PF00007
PF05463

PRINTS

PIRSF

SMART

SM00041

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6X4U4