InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CORT

Summary

InnateDB Protein

IDBP-89024.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CORT

Protein Name

cortistatin

Synonyms

CST-14; CST-17; CST-29;

Species

Homo sapiens

Ensembl Protein

ENSP00000366248

InnateDB Gene

IDBG-408494 (CORT)

Protein Structure

UniProt Annotation

Function

Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed in a subset of GABAergic cells in the cortex and hippocampus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0005179	hormone activity
GO:0005184	neuropeptide hormone activity

Biological Process

GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007268	synaptic transmission

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

InterPro

IPR018142 Somatostatin/Cortistatin, C-terminal

PFAM

PF03002

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O00230

PhosphoSite

PhosphoSite-O00230

TrEMBL

Q8IUV6

UniProt Splice Variant

Entrez Gene

1325

UniGene

RefSeq

NP_001293

HUGO

HGNC:2257

OMIM

602784

CCDS

CCDS117

HPRD

04150

IMGT

EMBL

AB000263 AF013252 AL354956 AY358561 BC040034 BC119724 BC119725 CH471130

GenPept

AAB66895 AAH40034 AAI19725 AAI19726 AAQ89950 BAA19770 CAI19195 EAW71650