InnateDB Protein
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IDBP-89036.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PPP2R4
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Protein Name
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protein phosphatase 2A activator, regulatory subunit 4
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Synonyms
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PP2A; PR53; PTPA;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000349726
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InnateDB Gene
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IDBG-89032 (PPP2R4)
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Protein Structure
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Function |
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine- protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A. {ECO:0000250, ECO:0000269PubMed:16916641, ECO:0000269PubMed:17333320}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:17333320}. Nucleus {ECO:0000269PubMed:17333320}.
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Disease Associations |
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Tissue Specificity |
Widely expressed.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
66
[view]
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Protein-Protein |
62
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0000413
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protein peptidyl-prolyl isomerization
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GO:0006200
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ATP catabolic process
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GO:0006457
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protein folding
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GO:0030472
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mitotic spindle organization in nucleus
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GO:0032515
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negative regulation of phosphoprotein phosphatase activity
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GO:0032516
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positive regulation of phosphoprotein phosphatase activity
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GO:0035307
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positive regulation of protein dephosphorylation
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GO:0035308
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negative regulation of protein dephosphorylation
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GO:0043065
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positive regulation of apoptotic process
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GO:0043085
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positive regulation of catalytic activity
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GO:0043666
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regulation of phosphoprotein phosphatase activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR004327
Phosphotyrosyl phosphatase activator, PTPA
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PFAM |
PF03095
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PRINTS |
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PIRSF |
PIRSF016325
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q15257
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PhosphoSite |
PhosphoSite-Q15257
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TrEMBL |
B7ZBQ0
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UniProt Splice Variant |
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Entrez Gene |
5524
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UniGene |
Hs.400740
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RefSeq |
NP_001258761
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HUGO |
HGNC:9308
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OMIM |
600756
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CCDS |
CCDS65156
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HPRD |
02858
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IMGT |
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EMBL |
AK222788
AK302043
AL158151
BC002545
BC011605
BT020119
CH471090
X73478
X86428
X86429
X86430
X86431
X86432
X86434
X86435
X86436
X86437
X86438
X86439
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GenPept |
AAH02545
AAH11605
AAV38922
BAD96508
BAG63436
CAA51873
CAA60163
CAB77601
CAB77602
CAB77603
CAM14695
CAP58847
EAW87876
EAW87882
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