Version 5.4
Homo sapiens Gene: PPP2R4
Summary
InnateDB Gene IDBG-89032.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP2R4
Gene Name protein phosphatase 2A activator, regulatory subunit 4
Synonyms PP2A; PR53; PTPA
Species Homo sapiens
Ensembl Gene ENSG00000119383
Encoded Proteins
IDBP-89034
protein phosphatase 2A activator, regulatory subunit 4
IDBP-89036
protein phosphatase 2A activator, regulatory subunit 4
IDBP-89038
protein phosphatase 2A activator, regulatory subunit 4
IDBP-89042
protein phosphatase 2A activator, regulatory subunit 4
IDBP-89044
protein phosphatase 2A activator, regulatory subunit 4
IDBP-89046
protein phosphatase 2A activator, regulatory subunit 4
IDBP-243740
protein phosphatase 2A activator, regulatory subunit 4
IDBP-382153
protein phosphatase 2A activator, regulatory subunit 4
IDBP-382158
protein phosphatase 2A activator, regulatory subunit 4
IDBP-382159
protein phosphatase 2A activator, regulatory subunit 4
IDBP-382160
protein phosphatase 2A activator, regulatory subunit 4
IDBP-382161
protein phosphatase 2A activator, regulatory subunit 4
IDBP-382162
protein phosphatase 2A activator, regulatory subunit 4
IDBP-382164
protein phosphatase 2A activator, regulatory subunit 4
IDBP-382168
protein phosphatase 2A activator, regulatory subunit 4
IDBP-382169
protein phosphatase 2A activator, regulatory subunit 4
IDBP-382171
protein phosphatase 2A activator, regulatory subunit 4
IDBP-382176
protein phosphatase 2A activator, regulatory subunit 4
IDBP-382180
protein phosphatase 2A activator, regulatory subunit 4
IDBP-382181
protein phosphatase 2A activator, regulatory subunit 4
IDBP-382182
protein phosphatase 2A activator, regulatory subunit 4
IDBP-382183
protein phosphatase 2A activator, regulatory subunit 4
IDBP-382184
protein phosphatase 2A activator, regulatory subunit 4
IDBP-382185
protein phosphatase 2A activator, regulatory subunit 4
IDBP-382187
protein phosphatase 2A activator, regulatory subunit 4
IDBP-382188
protein phosphatase 2A activator, regulatory subunit 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B\'/PR61, and B\'\'/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B\' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:129110950-129148946
Strand Forward strand
Band q34.11
Transcripts
ENST00000358994 ENSP00000351885
ENST00000357197 ENSP00000349726
ENST00000355007 ENSP00000347109
ENST00000347048 ENSP00000337412
ENST00000348141 ENSP00000335200
ENST00000337738 ENSP00000337448
ENST00000393370 ENSP00000377036
ENST00000455292 ENSP00000395499
ENST00000452489 ENSP00000394338
ENST00000445241 ENSP00000406997
ENST00000414331 ENSP00000399069
ENST00000417728 ENSP00000403542
ENST00000453358 ENSP00000393092
ENST00000417504 ENSP00000400314
ENST00000440346 ENSP00000393796
ENST00000455240 ENSP00000396660
ENST00000411917 ENSP00000405100
ENST00000423100 ENSP00000408316
ENST00000414510 ENSP00000408726
ENST00000436883 ENSP00000389312
ENST00000432124 ENSP00000416522
ENST00000435305 ENSP00000393196
ENST00000419582 ENSP00000394001
ENST00000432651 ENSP00000416661
ENST00000435132 ENSP00000387726
ENST00000434095 ENSP00000411604
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 66 [view]
Protein-Protein 62 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005102 receptor binding
GO:0005524 ATP binding
GO:0008160 protein tyrosine phosphatase activator activity
GO:0008601 protein phosphatase type 2A regulator activity
GO:0016887 ATPase activity
GO:0019211 phosphatase activator activity
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0051721 protein phosphatase 2A binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006200 ATP catabolic process
GO:0006457 protein folding
GO:0030472 mitotic spindle organization in nucleus
GO:0032515 negative regulation of phosphoprotein phosphatase activity
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0035307 positive regulation of protein dephosphorylation
GO:0035308 negative regulation of protein dephosphorylation
GO:0043065 positive regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0043666 regulation of phosphoprotein phosphatase activity
Cellular Component
GO:0000159 protein phosphatase type 2A complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0034704 calcium channel complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039515
View Gene Order
ENSBTAG00000001933
Not yet available
Pathways
NETPATH
NetPath_147
IL11 pathway
REACTOME
KEGG
INOH
INOH website
Insulin receptor signaling pathway
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID NCI
myc_represspathway
Validated targets of C-MYC transcriptional repression
p53regulationpathway
p53 pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.400740
RefSeq NM_001193397 NM_001271832 NM_021131 NM_178000 NM_178001 NM_178003
HUGO
OMIM
CCDS CCDS65156 CCDS6920 CCDS75917
HPRD 02858
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca