InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP2R4

Summary

InnateDB Protein

IDBP-89038.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP2R4

Protein Name

protein phosphatase 2A activator, regulatory subunit 4

Synonyms

PP2A; PR53; PTPA;

Species

Homo sapiens

Ensembl Protein

ENSP00000347109

InnateDB Gene

IDBG-89032 (PPP2R4)

Protein Structure

UniProt Annotation

Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine- protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A. {ECO:0000250, ECO:0000269PubMed:16916641, ECO:0000269PubMed:17333320}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:17333320}. Nucleus {ECO:0000269PubMed:17333320}.

Disease Associations

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	66 [view]
Protein-Protein	62 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005102	receptor binding
GO:0005524	ATP binding
GO:0008160	protein tyrosine phosphatase activator activity
GO:0008601	protein phosphatase type 2A regulator activity
GO:0016887	ATPase activity
GO:0019211	phosphatase activator activity
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0051721	protein phosphatase 2A binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0006200	ATP catabolic process
GO:0006457	protein folding
GO:0030472	mitotic spindle organization in nucleus
GO:0032515	negative regulation of phosphoprotein phosphatase activity
GO:0032516	positive regulation of phosphoprotein phosphatase activity
GO:0035307	positive regulation of protein dephosphorylation
GO:0035308	negative regulation of protein dephosphorylation
GO:0043065	positive regulation of apoptotic process
GO:0043085	positive regulation of catalytic activity
GO:0043666	regulation of phosphoprotein phosphatase activity

Cellular Component

GO:0000159	protein phosphatase type 2A complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0034704	calcium channel complex
GO:0070062	extracellular vesicular exosome