Version 5.4
Homo sapiens Protein: ADD3
Summary
InnateDB Protein IDBP-89139.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADD3
Protein Name adducin 3 (gamma)
Synonyms ADDL;
Species Homo sapiens
Ensembl Protein ENSP00000353286
InnateDB Gene IDBG-89137 (ADD3)
Protein Structure
UniProt Annotation
Function Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
Subcellular Localization Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Disease Associations
Tissue Specificity Isoform 1 is ubiquitously expressed. {ECO:0000269PubMed:8893809}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005200 structural constituent of cytoskeleton
GO:0005516 calmodulin binding
Biological Process
Cellular Component
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001303 Class II aldolase/adducin N-terminal
PFAM PF00596
PRINTS
PIRSF
SMART SM01007
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UEY8
PhosphoSite PhosphoSite-Q9UEY8
TrEMBL
UniProt Splice Variant
Entrez Gene 120
UniGene Hs.501012
RefSeq NP_063968
HUGO HGNC:245
OMIM 601568
CCDS CCDS7562
HPRD 03339
IMGT
EMBL AL590628 BC062559 BX647403 CH471066 D67031 U37122 Y14372 Y14373 Y14374 Y14375 Y14376 Y14377 Y14378 Y14379 Y14380 Y14381 Y14382 Y14383 Y14384
GenPept AAB17126 AAH62559 BAA23783 CAB51805 CAB51806 CAH71739 CAI46048 EAW49573 EAW49574

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca