Version 5.4
Homo sapiens Gene: ADD3
Summary
InnateDB Gene IDBG-89137.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADD3
Gene Name adducin 3 (gamma)
Synonyms ADDL
Species Homo sapiens
Ensembl Gene ENSG00000148700
Encoded Proteins
IDBP-89139
adducin 3 (gamma)
IDBP-89141
adducin 3 (gamma)
IDBP-89145
adducin 3 (gamma)
IDBP-808759
adducin 3 (gamma)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:109996368-110135565
Strand Forward strand
Band q25.1
Transcripts
ENST00000360162 ENSP00000353286
ENST00000356080 ENSP00000348381
ENST00000277900 ENSP00000277900
ENST00000468251
ENST00000484622
ENST00000487085
ENST00000459738
ENST00000495661
ENST00000497125
ENST00000475954
ENST00000496517
ENST00000468345
ENST00000473669
ENST00000486014
ENST00000488104
ENST00000488837
ENST00000472568
ENST00000492162
ENST00000488799
ENST00000479805
ENST00000611329 ENSP00000480646
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
GO:0005516 calmodulin binding
Biological Process
Cellular Component
GO:0000794 condensed nuclear chromosome
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005938 cell cortex
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025026
View Gene Order
ENSBTAG00000003265
Not yet available
Pathways
NETPATH
NetPath_24
TSLP pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.501012
RefSeq NM_001121 NM_016824 NM_019903 XM_005269529 XM_005269530 XM_005269531 XM_005269533 XM_005269534 XM_006717626 XM_006717627 XM_006717628
HUGO
OMIM
CCDS CCDS7561 CCDS7562
HPRD 03339
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca