InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADD3

Summary

InnateDB Protein

IDBP-89141.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADD3

Protein Name

adducin 3 (gamma)

Synonyms

ADDL;

Species

Homo sapiens

Ensembl Protein

ENSP00000348381

InnateDB Gene

IDBG-89137 (ADD3)

Protein Structure

UniProt Annotation

Function

Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.

Subcellular Localization

Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Disease Associations

Tissue Specificity

Isoform 1 is ubiquitously expressed. {ECO:0000269PubMed:8893809}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005198	structural molecule activity
GO:0005200	structural constituent of cytoskeleton
GO:0005516	calmodulin binding

Biological Process

Cellular Component

GO:0000794	condensed nuclear chromosome
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005938	cell cortex
GO:0016020	membrane