InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NTMT1

Summary

InnateDB Protein

IDBP-89171.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NTMT1

Protein Name

methyltransferase like 11A

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000361561

InnateDB Gene

IDBG-89167 (NTMT1)

Protein Structure

UniProt Annotation

Function

Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. {ECO:0000269PubMed:20481588, ECO:0000269PubMed:20668449, ECO:0000269PubMed:24090352}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:20668449, ECO:0000269PubMed:24090352}. Note=Predominantly nuclear.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008168	methyltransferase activity
GO:0008171	O-methyltransferase activity
GO:0008276	protein methyltransferase activity

Biological Process

GO:0007051	spindle organization
GO:0007059	chromosome segregation
GO:0008152	metabolic process
GO:0018016	N-terminal peptidyl-proline dimethylation
GO:0035572	N-terminal peptidyl-serine dimethylation
GO:0035573	N-terminal peptidyl-serine trimethylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001077 O-methyltransferase, family 2
IPR004033 UbiE/COQ5 methyltransferase
IPR008576 Protein of unknown function DUF858, methyltransferase-like
IPR013216 Methyltransferase type 11
IPR013217 Methyltransferase type 12
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF00891
PF01209
PF05891
PF08241
PF08242

PRINTS

PIRSF

PIRSF016958

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9BV86