InnateDB Protein
|
IDBP-89173.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
NTMT1
|
Protein Name
|
methyltransferase like 11A
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000361559
|
InnateDB Gene
|
IDBG-89167 (NTMT1)
|
Protein Structure
|
|
Function |
Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. {ECO:0000269PubMed:20481588, ECO:0000269PubMed:20668449, ECO:0000269PubMed:24090352}.
|
Subcellular Localization |
Nucleus {ECO:0000269PubMed:20668449, ECO:0000269PubMed:24090352}. Note=Predominantly nuclear.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
15
[view]
|
Protein-Protein |
15
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0008168
|
methyltransferase activity
|
GO:0008276
|
protein methyltransferase activity
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR008576
Protein of unknown function DUF858, methyltransferase-like
IPR029063
S-adenosyl-L-methionine-dependent methyltransferase-like
|
PFAM |
PF05891
|
PRINTS |
|
PIRSF |
PIRSF016958
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9BV86
|
PhosphoSite |
PhosphoSite-Q9BV86
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
28989
|
UniGene |
Hs.522433
|
RefSeq |
NP_001273730
|
HUGO |
HGNC:23373
|
OMIM |
613560
|
CCDS |
CCDS69682
|
HPRD |
10628
|
IMGT |
|
EMBL |
AF110776
AK290957
AK292332
AK298840
AL590369
BC001396
BC033234
|
GenPept |
AAF14859
AAH01396
AAH33234
BAF83646
BAF85021
BAG60968
CAI14507
CAI14508
|
|
|