InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SRM

Summary

InnateDB Protein

IDBP-89205.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRM

Protein Name

spermidine synthase

Synonyms

PAPT; SPDSY; SPS1; SRML1;

Species

Homo sapiens

Ensembl Protein

ENSP00000366156

InnateDB Gene

IDBG-89203 (SRM)

Protein Structure

UniProt Annotation

Function

Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine. {ECO:0000269PubMed:17585781}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004766	spermidine synthase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006595	polyamine metabolic process
GO:0008295	spermidine biosynthetic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process