InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EXOSC10

Summary

InnateDB Protein

IDBP-89215.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EXOSC10

Protein Name

exosome component 10

Synonyms

p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL; PMSCL2; RRP6; Rrp6p;

Species

Homo sapiens

Ensembl Protein

ENSP00000307307

InnateDB Gene

IDBG-89211 (EXOSC10)

Protein Structure

UniProt Annotation

Function

Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA. {ECO:0000250, ECO:0000269PubMed:14527413, ECO:0000269PubMed:16455498, ECO:0000269PubMed:17412707, ECO:0000269PubMed:17545563, ECO:0000269PubMed:18172165, ECO:0000269PubMed:19056938, ECO:0000269PubMed:20368444, ECO:0000269PubMed:20699273}.

Subcellular Localization

Cytoplasm. Nucleus, nucleolus. Nucleus. Note=Strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.

Experimentally validated
Total	82 [view]
Protein-Protein	82 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003824	catalytic activity
GO:0004532	exoribonuclease activity
GO:0005515	protein binding
GO:0008408	3'-5' exonuclease activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000460	maturation of 5.8S rRNA
GO:0000956	nuclear-transcribed mRNA catabolic process
GO:0006139	nucleobase-containing compound metabolic process
GO:0006396	RNA processing
GO:0044237	cellular metabolic process
GO:0071028	nuclear mRNA surveillance
GO:0071034	CUT catabolic process
GO:0071035	nuclear polyadenylation-dependent rRNA catabolic process
GO:0071044	histone mRNA catabolic process
GO:0071048	nuclear retention of unspliced pre-mRNA at the site of transcription
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic

Cellular Component

GO:0000176	nuclear exosome (RNase complex)
GO:0000178	exosome (RNase complex)
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0035327	transcriptionally active chromatin

Protein Structure and Domains

PDB ID

InterPro

IPR002121 HRDC domain
IPR002562 3\'-5\' exonuclease domain
IPR010997 HRDC-like
IPR012337 Ribonuclease H-like domain
IPR012588 Exosome-associated factor Rrp6, N-terminal

PFAM

PF00570
PF01612
PF08066

PRINTS

PIRSF

SMART

SM00341
SM00474

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q01780