InnateDB Protein
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IDBP-89238.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MXI1
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Protein Name
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MAX interactor 1
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Synonyms
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bHLHc11; MAD2; MXD2; MXI;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000331152
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InnateDB Gene
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IDBG-89236 (MXI1)
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Protein Structure
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Function |
Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.
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Subcellular Localization |
Nucleus.
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Disease Associations |
Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269PubMed:7773287}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
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Tissue Specificity |
High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006351
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transcription, DNA-templated
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GO:0008285
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negative regulation of cell proliferation
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GO:0042994
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cytoplasmic sequestering of transcription factor
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Cellular Component |
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PDB ID |
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InterPro |
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
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PFAM |
PF00010
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PRINTS |
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PIRSF |
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SMART |
SM00353
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TIGRFAMs |
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Modification |
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SwissProt |
P50539
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PhosphoSite |
PhosphoSite-P50539
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TrEMBL |
Q5V9L6
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UniProt Splice Variant |
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Entrez Gene |
4601
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UniGene |
Hs.743585
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RefSeq |
NP_569157
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HUGO |
HGNC:7534
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OMIM |
600020
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CCDS |
CCDS7563
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HPRD |
02486
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IMGT |
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EMBL |
AL360182
AY576484
BC012907
BC035128
BT007069
CH471066
CR536576
D63940
L07648
S78470
U32512
U32513
U32514
U32515
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GenPept |
AAA75508
AAC50446
AAD14282
AAH12907
AAH35128
AAP35732
AAT84074
BAA09972
CAG38813
CAI15475
CAI15476
CAI15479
CAI15480
EAW49565
EAW49567
EAW49568
EAW49569
EAW49570
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