Version 5.4
Homo sapiens Protein: MXI1
Summary
InnateDB Protein IDBP-89246.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MXI1
Protein Name MAX interactor 1
Synonyms bHLHc11; MAD2; MXD2; MXI;
Species Homo sapiens
Ensembl Protein ENSP00000354606
InnateDB Gene IDBG-89236 (MXI1)
Protein Structure
UniProt Annotation
Function Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.
Subcellular Localization Nucleus.
Disease Associations Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269PubMed:7773287}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Tissue Specificity High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 9 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0008285 negative regulation of cell proliferation
GO:0042994 cytoplasmic sequestering of transcription factor
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
PFAM PF00010
PRINTS
PIRSF
SMART SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P50539
PhosphoSite PhosphoSite-P50539
TrEMBL
UniProt Splice Variant
Entrez Gene 4601
UniGene Hs.743585
RefSeq NP_001008541
HUGO HGNC:7534
OMIM 600020
CCDS CCDS31284
HPRD 02486
IMGT
EMBL AL360182 BC012907 BC035128 BT007069 CH471066 CR536576 D63940 L07648 S78470 U32512 U32513 U32514 U32515
GenPept AAA75508 AAC50446 AAD14282 AAH12907 AAH35128 AAP35732 BAA09972 CAG38813 CAI15475 CAI15476 CAI15479 CAI15480 EAW49565 EAW49567 EAW49568 EAW49569 EAW49570

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca