InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FBXO2

Summary

InnateDB Protein

IDBP-89388.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXO2

Protein Name

F-box protein 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000346240

InnateDB Gene

IDBG-89386 (FBXO2)

Protein Structure

UniProt Annotation

Function

Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Microsome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0001948	glycoprotein binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0006464	cellular protein modification process
GO:0006508	proteolysis
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006516	glycoprotein catabolic process
GO:0008285	negative regulation of cell proliferation
GO:0016567	protein ubiquitination
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031396	regulation of protein ubiquitination

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0019005	SCF ubiquitin ligase complex
GO:0031090	organelle membrane
GO:0043197	dendritic spine
GO:0070062	extracellular vesicular exosome