InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FBXO2

Summary

InnateDB Gene

IDBG-89386.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXO2

Gene Name

F-box protein 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000116661

Encoded Proteins

IDBP-89388

F-box protein 2

IDBP-806871

F-box protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:11648367-11655785

Strand

Reverse strand

Band

p36.22

Transcripts

ENST00000354287	ENSP00000346240
ENST00000471501
ENST00000466919
ENST00000465901	ENSP00000473649
ENST00000475961

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0001948	glycoprotein binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0006464	cellular protein modification process
GO:0006508	proteolysis
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006516	glycoprotein catabolic process
GO:0008285	negative regulation of cell proliferation
GO:0016567	protein ubiquitination
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031396	regulation of protein ubiquitination

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0019005	SCF ubiquitin ligase complex
GO:0031090	organelle membrane
GO:0043197	dendritic spine
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000041556

View Gene Order

ENSBTAG00000007223

Not yet available

Pathways

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

hsa04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.132753 Hs.739100

RefSeq

NM_012168

HUGO

OMIM

CCDS

CCDS130

HPRD

06171

IMGT

EMBL

GenPept

RNA Seq Atlas