InnateDB Protein
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IDBP-89426.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TREX2
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Protein Name
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three prime repair exonuclease 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000333441
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InnateDB Gene
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IDBG-89424 (TREX2)
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Protein Structure
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Function |
Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair. {ECO:0000269PubMed:11279105}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Detected in heart, breast, prostate, skeletal muscle, testis, uterus, bone marrow, colon, small intestine, stomach and thymus. {ECO:0000269PubMed:11278605}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006055
Exonuclease
IPR012337
Ribonuclease H-like domain
IPR013520
Exonuclease, RNase T/DNA polymerase III
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PFAM |
PF00929
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PRINTS |
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PIRSF |
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SMART |
SM00479
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BQ50
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
11219
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UniGene |
Hs.644635
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RefSeq |
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HUGO |
HGNC:12270
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OMIM |
300540
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CCDS |
CCDS35437
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HPRD |
02299
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IMGT |
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EMBL |
AF151107
AF319570
AF319571
AF319572
AF319573
DQ145722
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GenPept |
AAD48776
AAK07617
AAK07618
AAK07619
AAK07620
AAZ38719
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