Version 5.4
Homo sapiens Protein: HAUS7
Summary
InnateDB Protein IDBP-89438.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HAUS7
Protein Name HAUS augmin-like complex, subunit 7
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000359231
InnateDB Gene IDBG-242765 (HAUS7)
Protein Structure
UniProt Annotation
Function Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269PubMed:19369198, ECO:0000269PubMed:19427217}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules.
Disease Associations
Tissue Specificity Detected in spleen, thymus, testis, ovary, small intestine and colon, with highest levels of expression in testis and ovary. {ECO:0000269PubMed:11163772}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004527 exonuclease activity
GO:0031996 thioesterase binding
Biological Process
GO:0007067 mitotic nuclear division
GO:0051225 spindle assembly
GO:0051297 centrosome organization
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005819 spindle
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0070652 HAUS complex
Protein Structure and Domains
PDB ID
InterPro IPR006055 Exonuclease
IPR012337 Ribonuclease H-like domain
IPR013520 Exonuclease, RNase T/DNA polymerase III
PFAM PF00929
PRINTS
PIRSF
SMART SM00479
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99871
PhosphoSite PhosphoSite-Q99871
TrEMBL Q06S70
UniProt Splice Variant
Entrez Gene 11219
UniGene Hs.170835
RefSeq
HUGO HGNC:12270
OMIM 300540
CCDS
HPRD 18695
IMGT
EMBL AF267739 AK300650 AL122036 BC008141 CA441020 CH471172 DQ650792 U82695 X99270
GenPept AAF75785 AAH08141 ABG43103 BAG62338 CAA67665 CAB59176 EAW72866 EAW72868 EAW72869 EAW72871

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca