Version 5.4
Homo sapiens Protein: HAUS7
Summary
InnateDB Protein IDBP-89440.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HAUS7
Protein Name HAUS augmin-like complex, subunit 7
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000359230
InnateDB Gene IDBG-242765 (HAUS7)
Protein Structure
UniProt Annotation
Function Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269PubMed:19369198, ECO:0000269PubMed:19427217}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules.
Disease Associations
Tissue Specificity Detected in spleen, thymus, testis, ovary, small intestine and colon, with highest levels of expression in testis and ovary. {ECO:0000269PubMed:11163772}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0031996 thioesterase binding
Biological Process
GO:0007067 mitotic nuclear division
GO:0051225 spindle assembly
GO:0051297 centrosome organization
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005819 spindle
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0070652 HAUS complex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99871
PhosphoSite PhosphoSite-Q99871
TrEMBL
UniProt Splice Variant
Entrez Gene 55559
UniGene Hs.170835
RefSeq NP_059988
HUGO HGNC:32979
OMIM 300540
CCDS CCDS35438
HPRD 18695
IMGT
EMBL AF267739 AK300650 AL122036 BC008141 CA441020 CH471172 U82695 X99270
GenPept AAF75785 AAH08141 BAG62338 CAA67665 CAB59176 EAW72866 EAW72868 EAW72869 EAW72871

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca