InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAD2L2

Summary

InnateDB Protein

IDBP-89492.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAD2L2

Protein Name

MAD2 mitotic arrest deficient-like 2 (yeast)

Synonyms

MAD2B; POLZ2; REV7;

Species

Homo sapiens

Ensembl Protein

ENSP00000235310

InnateDB Gene

IDBG-89488 (MAD2L2)

Protein Structure

UniProt Annotation

Function

Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation. {ECO:0000269PubMed:11459825, ECO:0000269PubMed:11459826, ECO:0000269PubMed:17296730, ECO:0000269PubMed:17719540, ECO:0000269PubMed:19443654}.

Subcellular Localization

Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:11717438}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	42 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0005515	protein binding
GO:0008432	JUN kinase binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001558	regulation of cell growth
GO:0006281	DNA repair
GO:0006302	double-strand break repair
GO:0006351	transcription, DNA-templated
GO:0007015	actin filament organization
GO:0007067	mitotic nuclear division
GO:0007094	mitotic spindle assembly checkpoint
GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0010944	negative regulation of transcription by competitive promoter binding
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0042177	negative regulation of protein catabolic process
GO:0042772	DNA damage response, signal transduction resulting in transcription
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060564	negative regulation of mitotic anaphase-promoting complex activity
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin
GO:2000678	negative regulation of transcription regulatory region DNA binding